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Stempie​n-Otero Laboratory

April Stempien-Otero, MD | Associate Professor

As a practicing heart failure transplant cardiologist who has participated in multicenter clinical trials and undergone
substantial additional training in basic science research, Dr. Stempien-Otero has developed the skills to bring bench to bedside studies to fruition. Her lab is using both mouse and human models to understand the role of bone marrow derived cells in cardiac repair. This studies include a Phase 1 trial to evaluate the histologic effects of injection of bone marrow cells into patients undergoing left ventricular assist device as a bridge to cardiac transplantation. In addition, her lab is collecting cardiac tissue from humans undergoing left ventricular assist device placement or cardiac transplantation. These samples are used for histologic analysis, and isolation of RNA from cell fractions.