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David Dichek

DAVID A. DICHEK, MD, FAHA

Professor of Medicine
Associate Director for Research
Adjunct Professor of Pathology​
John L. Locke, Jr. Family Endowed Chair 
in Cardiovascular Research and Treatment
 
University of Washington Medical Center 
1959 N.E. Pacific Street 
Campus Box 357710 
Seattle, WA 98195

 

EDUCATION AND TRAINING

  • Clinical Fellowship, Cardiology, Johns Hopkins Hospital, Baltimore, MD, and National Institutes of Health, Bethesda, MD, 1992
  • Residency, Internal Medicine, Massachusetts General Hospital, Boston, MA, 1987
  • MD, University of California, Los Angeles, CA, 1984
  • AB (magna cum laude), Romance Languages and Literatures, Princeton University, Princeton, NJ, 1976

BOARD CERTIFICATION

  • American Board of Internal Medicine, Cardiovascular Disease, 1993-2003; 2004-2014; 2014-2024
  • American Board of Internal Medicine, 1987-present
 

AREAS OF CLINICAL EXPERTISE

  • General Cardiology
 

SPECIAL ACCOMPLISHMENTS

  • Seattle's Top Docs; Castle Connolly and Seattle Magazine, 2010-2012, 2016
  • Atherosclerosis and Inflammation in the Cardiovascular System Study Section, CSR, NIH, 2014
  • Irvine Page Young Investigator Award Selection Committee, AHA, 2014-Present
  • John Locke Jr., Family Endowed Chair in Cardiovascular Research and Treatment, 2001-present
  • Fellow of the American Heart Association, 2001-present
  • Editorial Boards: Circulation, 1996-2008; Circulation Research, 1996-2008; Human Gene Therapy, 1998-2009; Arteriosclerosis, Thrombosis, and Vascular Biology, 2001-present
  • Special Recognition Award, ATVB Council of the American Heart Association, 2008
  • Leadership Committee, Council of Arteriosclerosis, Thrombosis and Vascular Biology, AHA, 2006-2008
  • Pathology A Study Section, NIH, 1999-2001
  • Ad hoc reviewer, Recombinant DNA Advisory Committee, NIH, 2000
  • Established Investigator, AHA, 1997-2000
  • Vascular Biology Study Section, National AHA, 1995-1999; 2011-2014
  • Stafford Warren Medal, UCLA Medical School, given to the graduating student with the highest academic ranking, 1984.
  • Phi Beta Kappa, Princeton University, 1976
  
 

CURRENT RESEARCH INTERESTS

  • Cardiovascular Gene Therapy
  • Mechanisms of Atherosclerosis and Aneurysm Formation
  • Roles of Transforming Growth Factor Beta Signaling in Blood Vessels
 

 Selected Publications

 
 
Hu JH, Wei H, Jaffe M, Airhart N, Du L, Angelov SN, Yan J, Allen JK, Kang I, Wight T, Fox K, Smith A, Enstrom R, and Dichek DA. Postnatal deletion of the type II TGF-beta receptor in smooth muscle cells causes severe aortopathy in mice. Arterioscler. Thromb. Vasc. Biol. 2015; 35:2647–2656.
 
 
Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT, Stolz DB, Davis EC, and Dichek DA. TGF-beta signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis. Arterioscler. Thromb. Vasc. Biol. 2012; 32:e1–e11.
 
 
 
Flynn R, Qian K, Tang C, Dronadula N, Buckler J, Jiang B, Wen S, Dichek HL, and Dichek DA. Expression of apolipoprotein A-I in rabbit carotid endothelium protects against atherosclerosis. Mol Ther 2011; 19:1833–1841.
 
 
 
Hu JH, Du L, Chu T, Otsuka G, Dronadula N, Jaffe M, Gill SE, Parks WC, and Dichek DA. Overexpression of urokinase by plaque macrophages causes histologic features of plaque rupture and increases vascular MMP activity in aged apo E-null mice. Circulation 2010;121:1637–1644.
 
 
 
Kremen M, Krishnan R, Emery I, Hu JH, Slezicki KI, Wu A, Qian K, Du L, Plawman A, Stempien-Otero A, and Dichek DA. Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice. Proc Natl Acad Sc. USA 2008;105:17109–17114.
 
 
 
Cozen AE, Moriwaki H, Kremen M, DeYoung MB, Dichek HL, Slezicki KI, Young SG, Véniant M, and Dichek DA. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 2004;109:2129–2135
 
 
 
Wen S, Graf S, Massey P, and Dichek DA. Improved vascular gene transfer with a helper-dependent adenoviral vector. Circulation 2004;110:1484–1491.
 
 
 
Moriwaki H, Stempien-Otero A, Kremen M, Cozen AE, and Dichek DA. Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice Circ Res 2004;95:637–644.
 
 
 
Schulick AH, Taylor AJ, Zuo W, Qiu CB, Dong G, Woodward R, Agah R, Roberts AB, Virmani R, and Dichek DA. Overexpression of TGF-beta 1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia. Proc. Natl. Acad. Sci. USA 1998; 95:6983–6988.
 
 
 
Rade JJ, Schulick AH, Virmani R, and Dichek DA. Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat Med 1996; 2:293–298.