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W. Robb MacLellan


Professor of Medicine and Division Head, Cardiology

Robert A. Bruce Endowed Chair in Cardiovascular Research

Professor of Physiology


University of Washington Medical Center
1959 NE Pacific St.
Box 356422
Seattle, WA  98195-6422



  • Fellowship in Cardiology, Baylor College of Medicine, Houston, TX, 1991-1995
  • Postdoctoral Fellowship in Molecular Cardiology, Baylor College of Medicine, Houston, TX, 1991-1993
  • Residency, Internal Medicine, University of Toronto, Canada, 1988-1991
  • MD, University of Toronto, Canada, 1988





  • Diplomate of the Certification Board of Nuclear Cardiology, 2004
  • Fellow of the Royal College of Physicians of Canada, Cardiology, 1995
  • Diplomate of the American Board of Internal Medicine, Cardiovascular Medicine (recertified in 2005), 1995
  • Fellow of the Royal College of Physicians of Canada, Internal Medicine, FRPC(C), 1992
  • Diplomate of the American Board of Internal Medicine, 1992




 Selected Publications

MacLellan WR, Wang Y, Lusis AJ "Systems-based approaches to cardiovascular disease." Nature reviews. Cardiology 2012 Mar; 9; 3; 172-84
Deng MC, Ardehali A, Shemin R, Hickey A, MacLellan WR, Fonarow G "Relative roles of heart transplantation and long-term mechanical circulatory support in contemporary management of advanced heart failure - a critical appraisal 10 years after REMATCH." European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2011 Oct; 40; 4; 781-2
Sdek P, Zhao P, Wang Y, Huang CJ, Ko CY, Butler PC, Weiss JN, Maclellan WR "Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes." The Journal of cell biology 2011 Aug; 194; 3; 407-23
Angelis E, Zhao P, Zhang R, Goldhaber JI, Maclellan WR "The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo." Journal of molecular and cellular cardiology 2011 Dec; 51; 6; 919-26
Horwich TB, Middlekauff HR, Maclellan WR, Fonarow GC "Statins do not significantly affect muscle sympathetic nerve activity in humans with nonischemic heart failure: a double-blind placebo-controlled trial." Journal of cardiac failure 2011 Nov; 17; 11; 879-86
Mungrue IN, Zhao P, Yao Y, Meng H, Rau C, Havel JV, Gorgels TG, Bergen AA, MacLellan WR, Drake TA, Boström KI, Lusis AJ "Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model." Arteriosclerosis, thrombosis, and vascular biology 2011 Dec; 31; 12; 2806-12
Gluck JM, Rahgozar P, Ingle NP, Rofail F, Petrosian A, Cline MG, Jordan MC, Roos KP, Maclellan WR, Shemin RJ, Heydarkhan-Hagvall S "Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering." Journal of biomedical materials research. Part B, Applied biomaterials 2011 Oct; 99; 1; 180-90
Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR "Recapitulation of the embryonic cardiovascular progenitor cell niche." Biomaterials 2011 Apr; 32; 11; 2748-56
Nsair A, MacLellan WR "Induced pluripotent stem cells for regenerative cardiovascular therapies and biomedical discovery." Advanced drug delivery reviews 2011 Apr; 63; 4-5; 324-30
Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, Rohr J, Ratan RR "Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration." The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May; 31; 18; 6858-70
Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF "Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy." Experimental eye research 2010 Feb; 90; 2; 223-37
Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, Wang Y, Jin ES, Jeffrey FM, Portman M, Maclellan WR "Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice." The Journal of clinical investigation 2010 May; 120; 5; 1494-505
Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM "Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells." Proceedings of the National Academy of Sciences of the United States of America 2010 Aug; 107; 31; 13742-7