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April Stempien-Otero


Associate Professor of Medicine
Associate Program Director for Research, Cardiology Fellowship
Craig Tall Family Endowed Chair in Heart Failure Research
Attending Physician, University of Washington Medical Center
UW Research - South Lake Union Complex
850 Republican Street, Brotman 142
Box 358050
Seattle, WA 98109


  • Cardiology Fellowship, University of Washington (Chief Fellow), Seattle, WA, 1997
  • Internship and Residency, University of Virginia (Chief Resident), Charlottesville, VA, 1993
  • MD, University of Connecticut School of Medicine, Farmington, CT, 1990
  • BA, Dartmouth College, Hanover, NH, 1986


  • Advanced Heart Failure and Transplant Cardiology, 2014
  • American Board of Internal Medicine, Cardiovascular Diseases, 1997, 2007
  • American Board of Internal Medicine, 1994, 2007



  • Congestive Heart Failure and Cardiac Transplantation
  • Heart Failure in Adult Congenital Heart Disease



  • CME Teacher of the Year, University of Washington School of Medicine, 2006
  • Vice President, Executive Board, American Heart Association, Metro King County, 2003-2004
  • Mentored Physician Scientist Award, NIH, 2002
  • Best Doctors in America, 2002-present
  • ATVB Merit Award, American Heart Association Annual Meeting, 1997
  • Fellowship Award, American Heart Association, Washington Affiliate, 1996



 Selected Publications

Minami E, Castellani C, Malchodi L, Deem J, Bertko K, Meznarich J, Dishmon M, Murry CE, Stempien-Otero A. The role of macrophage-derived urokinase plasminogen activator in myocardial infarct repair Urokinase attenuates ventricular remodeling. J. Mol. Cell. Cardio. Sep;49(3):516-24, 2010.
Kremen M, Krishnan R, Emery I, Hu JH, Slezicki KI, Wu A, Qian K, Du L, Plawman A, Stempien-Otero A, Dichek DA. Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice. Proc. Natl. Acad. Sci. U.S.A. 105:17109-17114, 2008.
Moorman AJ, Mozaffarian D, Wilkinson CW, Lawler RL, McDonald GB, Crane BA, Spertus JA, Russo JE, Stempien-Otero AS, Sullivan MD, Levy WC "In patients with heart failure elevated soluble TNF-receptor 1 is associated with higher risk of depression." Journal of cardiac failure 2007 Nov; 13; 9; 738-43
Stempien-Otero A, Plawman A, Meznarich J, Dyamenahalli T, Otsuka G, Dichek DA, Mechanisms of cardiac fibrosis induced by urokinase plasminogen Activator, J. Biol. Chem. 281:15345–15351, 2006.
Moriwaki, H, Stempien-Otero, A, Kremen, M, Cozen, AE, Dichek, DA, Overexpression of uronkinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice, Circ. Res. 941-8, 2004.